【产品介绍】BRG1 protein (brahma-related gene 1) is a member of SWI/SNF family which mediates ATP-dependent chromatin remodeling processes. BRG is a central catalytic ATPase of the SWI/SNF chromatin-remodeling complex, where it uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. Considered a major co-regulator of transcription, BRG1 has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. BRG1 appears to be a critical modulator of transcriptional regulation in cellular processes such as transcriptional regulation, replication, DNA repair and recombination (1, 2). BRG1 (SMARCA4),Rabbit Monoclonal Antibod Recommended Applications WB, IHC, ICC Applications and Recommended Dilution Factors WB: 1:1,000 - 5,000 IHC: 1:100 - 250 ICC: 1:100 - 250 Species Reactivity * Human *Cross reactivity determined by western blot only. BRG1 (SMARCA4),Rabbit Monoclonal Antibod Products Data Western blot analysis on A) K562 and B) Molt-4 cell lysates using anti-BRG1 RabMAb (cat. #2776-1). Immunofluorescent staining of HeLa cells using anti-BRG1 RabMAb (cat# 2776-1) Immunohistochemical analysis of paraffin-embedded BRG1 (SMARCA4),Rabbit Monoclonal Antibod human colon tissue using anti-BRG1 RabMAb (cat# 2776-1) Specificity A synthetic peptide corresponding to residues of human BRG1 protein was used as an immunogen |